ConclusionĪn ideal CAD application for engineering biological systems would provide features such as: building and simulating networks, analyzing robustness of networks, and searching databases for components that meet the design criteria. Downloads, documentation, and tutorials are available at. TinkerCell is a free and open-source project under the Berkeley Software Distribution license. Such modules can be connected to each other, forming larger modular networks. TinkerCell supports the notion of a module, which are networks with interfaces. Models that are constructed using these parts can be analyzed using various third-party C and Python programs that are hosted by TinkerCell via an extensive C and Python application programming interface (API). Each part in this hierarchy consists of a set of attributes that define the part, such as sequence or rate constants. TinkerCell is a visual modeling tool that supports a hierarchy of biological parts. ResultsĪn application named TinkerCell has been developed in order to serve as a CAD tool for synthetic biology. Using a CAD application, it would be possible to construct models using available biological "parts" and directly generate the DNA sequence that represents the model, thus increasing the efficiency of design and construction of synthetic networks. In this field, computer-aided design (CAD) is necessary in order to bridge the gap between computational modeling and biological data. Synthetic biology brings together concepts and techniques from engineering and biology.
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